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Article

Putative malignant hyperthermia mutation CaV1.1-R174W is insufficient to trigger a fulminant response to halothane or confer heat stress intolerance.

The Journal of biological chemistry - 1 Aug 2023

Feng Wei, Lopez Jose R, Antrobus Shane, Zheng Jing, Uryash Arkady, Dong Yao, Beqollari Donald, Bannister Roger A, Hopkins Philip M, Beam Kurt G, Allen Paul D, Pessah Isaac N

Abstract excerpt

Malignant hyperthermia susceptibility (MHS) is an autosomal dominant pharmacogenetic disorder that manifests as a hypermetabolic state when carriers are exposed to halogenated volatile anesthetics or depolarizing muscle relaxants. In animals, heat stress intolerance is also observed. MHS is linked to over 40 variants in RYR1 that are classified as pathogenic for diagnostic purposes. More recently, a few rare...

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Share to Large-Conductance Calcium-Activated Potassium Channel alpha Subunits

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Source

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Identifiers

PMID: 37392848
DOI: 10.1016/j.jbc.2023.104992
PMCID: PMC10413282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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