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Mitochondrial retrograde signalling in neurological disease

3 May 2020

Abstract excerpt

Neuronal mitochondrial dysfunction causes primary mitochondrial diseases and likely contributes to neurodegenerative diseases including Parkinson's and Alzheimer's disease. Mitochondrial dysfunction has also been documented in neurodevelopmental disorders such as tuberous sclerosis complex and autism spectrum disorder. Only symptomatic treatments exist for neurodevelopmental disorders, while neurodegenerative...

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PMID: 32362256
DOI: 10.1098/rstb.2019.0415

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