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Article

Association between the hypomethylation of osteopontin and integrin β3 promoters and vascular smooth muscle cell phenotype switching in great saphenous varicose veins.

International journal of molecular sciences - 17 Oct 2014

Jiang Han, Lun Yu, Wu Xiaoyu, Xia Qian, Zhang Xiaoyu, Xin Shijie, Zhang Jian

Abstract excerpt

Lower extremity varicose veins are a common condition in vascular surgery and proliferation of vascular smooth muscle cells (VSMCs) in the intima is a significant pathological feature of varicosity. However, the pathogenesis of varicose veins is not fully understood. Osteopontin (OPN) could promo...

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Share to DNA Methylation
Share to Gene Expression Regulation
Share to Integrin beta3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Osteopontin

Share to Promoter Regions, Genetic

Share to Varicose Veins

Source

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Identifiers

PMID: 25329616
DOI: 10.3390/ijms151018747
PMCID: PMC4227244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25329616-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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