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Article

Association between the hypomethylation of osteopontin and integrin β3 promoters and vascular smooth muscle cell phenotype switching in great saphenous varicose veins.

International journal of molecular sciences - 17 Oct 2014

Jiang Han, Lun Yu, Wu Xiaoyu, Xia Qian, Zhang Xiaoyu, Xin Shijie, Zhang Jian

Abstract excerpt

Lower extremity varicose veins are a common condition in vascular surgery and proliferation of vascular smooth muscle cells (VSMCs) in the intima is a significant pathological feature of varicosity. However, the pathogenesis of varicose veins is not fully understood. Osteopontin (OPN) could promote the migration and adhesion of VSMCs through the cell surface receptor integrin β3 and the cooperation of OPN and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Integrin beta3

Share to Muscle, Smooth, Vascular

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 25329616
DOI: 10.3390/ijms151018747
PMCID: PMC4227244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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