Article
Phenotypical Characterization of Spleen Remodeling in Murine Experimental Visceral Leishmaniasis.
Frontiers in immunology - 1 Jan 2020
de Melo Caroline Vilas Boas, Hermida Micely D'El-Rei, Mesquita Bianca R, Fontes Jonathan L M, Koning Jasper J, Solcà Manuela da Silva, Benevides Bruno B, Mota Girlândia B S, Freitas Luiz A R, Mebius Reina E, Dos-Santos Washington L C
Abstract excerpt
Background: Visceral leishmaniasis (VL) is caused by Leishmania infantum or L. donovani infection. One of the main problems related to this disease is the emergence of severe clinical forms with a lethality of 5-20%, even while under specific treatment. In humans and other species susceptible to fatal VL, such as dogs and hamsters, the disruption of splenic white pulp (WP) is accompanied by disease progression....
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