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Article

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment.

Nature - 1 Apr 2020

Lammert Catherine R, Frost Elizabeth L, Bellinger Calli E, Bolte Ashley C, McKee Celia A, Hurt Mariah E, Paysour Matt J, Ennerfelt Hannah E, Lukens John R

Abstract excerpt

Neurodevelopment is characterized by rapid rates of neural cell proliferation and differentiation followed by massive cell death in which more than half of all recently generated brain cells are pruned back. Large amounts of DNA damage, cellular debris, and by-products of cellular stress are generated during these neurodevelopmental events, all of which can potentially activate immune signalling. How the immune...

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Identifiers

PMID: 32350463
DOI: 10.1038/s41586-020-2174-3
PMCID: PMC7788527

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