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Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target

9 Sept 2020

Abstract excerpt

Mounting evidence has associated Zika virus (ZIKV) infection with congenital malformations, including microcephaly, which raises global alarm. Nonetheless, mechanisms by which ZIKV disrupts neurogenesis and causes microcephaly are far from being understood. In this study, we discovered direct effects of ZIKV on neural progenitor cell development by inducing caspase-1- and gasdermin D (GSDMD)-mediated pyroptotic...

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PMID: 32907937
DOI: 10.1073/pnas.2007773117

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