Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perinatal fluoxetine treatment and dams' early life stress history alter affective behavior in rat offspring depending on serotonin transporter genotype and sex.

Behavioural brain research - 17 Aug 2020

Houwing Danielle J, Schuttel Kirsten, Struik Eline L, Arling Chantal, Ramsteijn Anouschka S, Heinla I, Olivier Jocelien D A

Abstract excerpt

Many women diagnosed with a major depression continue or initiate antidepressant treatment during pregnancy. Both maternal stress and selective serotonin inhibitor (SSRI) antidepressant treatment during pregnancy have been associated with changes in offspring behavior, including increased anxiety and depressive-like behavior. Our aim was to investigate the effects of the SSRI fluoxetine (FLX), with and without...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Affect
Share to Antidepressive Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anxiety Disorders

Share to Depressive Disorder

Share to Fluoxetine

Share to Maternal Behavior

Share to Prenatal Exposure Delayed Effects

Share to Selective Serotonin Reuptake Inhibitors

Source

Identifiers

PMID: 32339551
DOI: 10.1016/j.bbr.2020.112657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perinatal fluoxetine treatment and dams' early life stress history alter affective behavior in rat offspring depending on serotonin transporter genotype and sex.PMID 32339551Read ↗

A novel murine model to study the impact of maternal depression and antidepressant treatment on biobehavioral functions in the offspringSemantic proximity Read ↗

Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brainSemantic proximity Read ↗

Differential Effects of Prenatal Stress in 5-Htt Deficient Mice: Towards Molecular Mechanisms of Gene × Environment InteractionsSemantic proximity Read ↗

Prenatal stress produces sex-specific changes in depression-like behavior in rats: implications for increased vulnerability in femalesSemantic proximity Read ↗

Pre-reproductive stress in adolescent female rats alters oocyte microRNA expression and offspring phenotypes: pharmacological interventions and putative mechanisms.Semantic proximity Read ↗

Perinatal Administration of a Selective Serotonin Reuptake Inhibitor Induces Impairments in Reproductive Function and Follicular Dynamics in Female Rat Offspring.Semantic proximity Read ↗

Offspring's own serotonin transporter genotype, independently from the maternal one, increases anxiety- and depression-like behavior and alters neuroplasticity markers in rats.Semantic proximity Read ↗

Both maternal care received and genotype influence stress-related phenotype in female rats.Semantic proximity Read ↗

Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats.Semantic proximity Read ↗

The effects of maternal SSRI exposure on the serotonin system, prefrontal protein expression and behavioral development in male and female offspring ratsSemantic proximity Read ↗

Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus.Semantic proximity Read ↗

THE EFFECT OF SERTRALINE AND VOLUNTARY EXERCISE DURING PREGNANCY ON LITTER CHARACTERISTICS AND POSTNATAL AFFECTIVE BEHAVIOUR IN RAT DAMSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.