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Article

Darier disease is associated with heart failure: a cross-sectional case-control and population based study.

Scientific reports - 23 Apr 2020

Bachar-Wikstrom Etty, Curman Philip, Ahanian Tara, Leong Ivone U S, Larsson Henrik, Cederlöf Martin, Wikstrom Jakob D

Abstract excerpt

Human data supporting a role for endoplasmic reticulum (ER) stress and calcium dyshomeostasis in heart disease is scarce. Darier disease (DD) is a hereditary skin disease caused by mutations in the ATP2A2 gene encoding the sarcoendoplasmic-reticulum Ca2+ ATPase isoform 2 (SERCA2), which causes calcium dyshomeostasis and ER stress. We hypothesized that DD patients would have an increased risk for common heart...

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Identifiers

PMID: 32327688
DOI: 10.1038/s41598-020-63832-9
PMCID: PMC7181854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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