Article
Different associations of tumor PIK3CA mutations and clinical outcomes according to aspirin use among women with metastatic hormone receptor positive breast cancer.
BMC cancer - 23 Apr 2020
McCarthy Anne Marie, Kumar Nitya Pradeep, He Wei, Regan Susan, Welch Michaela, Moy Beverly, Iafrate A John, Chan Andrew T, Bardia Aditya, Armstrong Katrina
Abstract excerpt
INTRODUCTION: The relationships among PIK3CA mutations, medication use and tumor progression remains poorly understood. Aspirin use post-diagnosis may modify components of the PI3K pathway, including AKT and mTOR, and has been associated with lower risk of breast cancer recurrence and mortality. We assessed time to metastasis (TTM) and survival with respect to aspirin use and tumor PIK3CA mutations among women...
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