Article
SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2023
Conte Benedetta, Boni Luca, Bisagni Giancarlo, Durando Antonio, Sanna Giovanni, Gori Stefania, Garrone Ornella, Tamberi Stefano, De Placido Sabino, Schettini Francesco, Pazzola Antonio, Ponzone Riccardo, Montemurro Filippo, Lunardi Gianluigi, Notaro Rosario, De Angioletti Maria, Turletti Anna, Mansutti Mauro, Puglisi Fabio, Frassoldati Antonio, Porpiglia Mauro, Fabi Alessandra, Generali Daniele, Scognamiglio Giovanni, Rossi Maura, Brasó-Maristany Fara, Prat Aleix, Cardinali Barbara, Piccioli Patrizia, Serra Martina, Lastraioli Sonia, Bighin Claudia, Poggio Francesca, Lambertini Matteo, Del Mastro Lucia
Abstract excerpt
PURPOSE: In estrogen receptor-positive (ER+) breast cancer, single-nucleotide polymorphisms (SNP) in the aromatase gene might affect aromatase inhibitors (AI) metabolism and efficacy. Here, we assessed the impact of SNP on prognosis and toxicity of patients receiving adjuvant letrozole. EXPERIMENTAL DESIGN: We enrolled 886 postmenopausal patients in the study. They were treated with letrozole for 2 to 5 years...
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