Article
Radio-adaptive response, individual radio-sensitivity and correlation of base excision repair gene polymorphism (hOGG1, APE1, XRCC1, and LIGASE1) in human peripheral blood mononuclear cells exposed to gamma radiation.
Environmental and molecular mutagenesis - 1 Jun 2020
Toprani Sneh M, Das Birajalaxmi
Abstract excerpt
Radio-adaptive response (RAR) is a biological mechanism, where cells primed with a low dose exhibit reduced DNA damage with a high challenging dose. Single nucleotide polymorphisms (SNPs) of DNA repair genes including base excision repair (BER) pathway are known to be associated with radio-sensitivity but involvement in RAR is not yet understood. In the present study, attempt was made to correlate genotype...
Topics
- DNA Damage
- DNA Glycosylases
- DNA Ligase ATP
- DNA Repair
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Gamma Rays
- Gene Expression Regulation
- Gene Frequency
- Genotype
- Humans
- Leukocytes, Mononuclear
- Polymorphism, Single Nucleotide
- RNA, Messenger