Article
DNA damage response pathway in radioadaptive response.
Mutation research - 25 Jul 2002
Sasaki Masao S, Ejima Yosuke, Tachibana Akira, Yamada Toshiko, Ishizaki Kanji, Shimizu Takashi, Nomura Taisei
Abstract excerpt
Radioadaptive response is a biological defense mechanism in which low-dose ionizing irradiation elicits cellular resistance to the genotoxic effects of subsequent irradiation. However, its molecular mechanism remains largely unknown. We previously demonstrated that the dose recognition and adaptive response could be mediated by a feedback signaling pathway involving protein kinase C (PKC), p38 mitogen activated...
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