Article
Identification of a new p53 responsive element in the promoter region of anillin.
International journal of molecular medicine - 1 May 2020
Ma Jiao, Liu Xinying, Liu Pengyi, Lu Wenqing, Shen Xinxin, Ma Ruixiang, Zong Hongliang
Abstract excerpt
The expression of anillin mRNA and protein is regulated in a cell cycle‑dependent manner. However, the mechanism underlying this process is unclear. Previous studies analyzing the sequence of the 5'‑untranslated region of anillin have unveiled several putative p53 binding sites. Therefore, the present study hypothesized that the anillin gene may be repressed by p53 and that the commonly observed mutation (or loss...
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