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Article

Nrf2 modulates immunosuppressive ability and cellular senescence of human umbilical cord mesenchymal stem cells.

Biochemical and biophysical research communications - 11 Jun 2020

Jie Zhang, Huan Yao, Mengyun Wu, Yasha Li, Huafeng Pan, Ke Yang

Abstract excerpt

In the application of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) as clinical therapeutics, long term cells ex vivo expansion results in decline in their function. It has been widely concerned that cellular senescence is associated with UC-MSCs immunomodulatory ability. In this study, we evaluated the effects of consecutive passages on cellular senescence and the immunomodulatory abilities of...

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Identifiers

PMID: 32317184
DOI: 10.1016/j.bbrc.2020.03.175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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