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Article

A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging.

PloS one - 1 Jan 2014

Yu Kyung-Rok, Lee Jin Young, Kim Hyung-Sik, Hong In-Sun, Choi Soon Won, Seo Yoojin, Kang Insung, Kim Jae-Jun, Lee Byung-Chul, Lee SeungHee, Kurtz Andreas, Seo Kwang-Won, Kang Kyung-Sun

Abstract excerpt

Because human mesenchymal stem cells (hMSC) have profound immunomodulatory effects, many attempts have been made to use hMSCs in preclinical and clinical trials. For hMSCs to be used in therapy, a large population of hMSCs must be generated by in vitro expansion. However, the immunomodulatory changes following the in vitro expansion of hMSCs have not been elucidated. In this study, we evaluated the effect of...

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Identifiers

PMID: 25090227
DOI: 10.1371/journal.pone.0102426
PMCID: PMC4121064

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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