Article
Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway.
Molecular biology of the cell - 1 Mar 2005
Terai Masanori, Uyama Taro, Sugiki Tadashi, Li Xiao-Kang, Umezawa Akihiro, Kiyono Tohru
Abstract excerpt
Human umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) are expected to serve as an excellent alternative to bone marrow-derived human mesenchymal stem cells. However, it is difficult to study them because of their limited life span. To overcome this problem, we attempted to produce a strain of UCBMSCs with a long life span and to investigate whether the strain could maintain phenotypes in vitro....
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