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Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6

15 Dec 2020

Abstract excerpt

Abstract Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy to treat many degenerative diseases. Accumulating evidence shows that the function of MSCs declines with age, thus limiting their regenerative capacity. Nonetheless, the underlying mechanisms that control MSC ageing are not well understood. We show that compared with bone marrow-MSCs (BM-MSCs) isolated from young and aged samples,...

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PMID: 33323934
DOI: 10.1038/s41419-020-03289-w

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