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Article

The Importance of Porins and β-Lactamase in Outer Membrane Vesicles on the Hydrolysis of β-Lactam Antibiotics.

International journal of molecular sciences - 17 Apr 2020

Kim Si Won, Lee Jung Seok, Park Seong Bin, Lee Ae Rin, Jung Jae Wook, Chun Jin Hong, Lazarte Jassy Mary S, Kim Jaesung, Seo Jong-Su, Kim Jong-Hwan, Song Jong-Wook, Ha Min Woo, Thompson Kim D, Lee Chang-Ro, Jung Myunghwan, Jung Tae Sung

Abstract excerpt

Gram-negative bacteria have an outer membrane inhibiting the entry of antibiotics. Porins, found within the outer membrane, are involved in regulating the permeability of β-lactam antibiotics. β-lactamases are enzymes that are able to inactivate the antibacterial properties of β-lactam antibiotics. Interestingly, porins and β-lactamase are found in outer membrane vesicles (OMVs) of β-lactam-resistant Escherichia...

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Identifiers

PMID: 32316670
DOI: 10.3390/ijms21082822
PMCID: PMC7215730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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