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Article

Prognostic significance of an invasive leader cell-derived mutation cluster on chromosome 16q.

Cancer - 1 Jul 2020

Pedro Brian, Rupji Manali, Dwivedi Bhakti, Kowalski Jeanne, Konen Jessica M, Owonikoko Taofeek K, Ramalingam Suresh S, Vertino Paula M, Marcus Adam I

Abstract excerpt

BACKGROUND: Intratumoral heterogeneity is defined by subpopulations with varying genotypes and phenotypes. Specialized, highly invasive leader cells and less invasive follower cells are phenotypically distinct subpopulations that cooperate during collective cancer invasion. Because leader cells are a rare subpopulation that would be missed by bulk sequencing, a novel image-guided genomics platform was used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32315457
DOI: 10.1002/cncr.32903
PMCID: PMC7275903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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