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Article

Single-cell RNA-sequencing reveals profound changes in circulating immune cells in patients with heart failure.

Cardiovascular research - 21 Jan 2021

Abplanalp Wesley T, John David, Cremer Sebastian, Assmus Birgit, Dorsheimer Lena, Hoffmann Jedrzej, Becker-Pergola Graziella, Rieger Michael A, Zeiher Andreas M, Vasa-Nicotera Mariuca, Dimmeler Stefanie

Abstract excerpt

AIMS: Identification of signatures of immune cells at single-cell level may provide novel insights into changes of immune-related disorders. Therefore, we used single-cell RNA-sequencing to determine the impact of heart failure on circulating immune cells. METHODS AND RESULTS: We demonstrate a significant change in monocyte to T-cell ratio in patients with heart failure, compared to healthy subjects, which were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32311026
DOI: 10.1093/cvr/cvaa101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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