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Molecular Insights into Mechanisms of the Cell Death Program:Role in the Progression of Neurodegenerative Disorders

1 Sept 2006

Abstract excerpt

Synaptic degeneration and death of neurons in limbic and cortical brain regions are the fundamental processes responsible for the manifestation of cognitive dysfunction and behavioural abnormalities in Alzheimer's disease (AD). Despite the various genetic and environmental factors, and the aging process itself that may lead to the manifestation of AD, multiple evidence from studies in experimental models and in...

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PMID: 17017859
DOI: 10.2174/156720506778249461

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