Article
Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy.
Oncotarget - 28 Aug 2015
Vacchelli Erika, Semeraro Michaela, Enot David P, Chaba Kariman, Poirier Colame Vichnou, Dartigues Peggy, Perier Aurelie, Villa Irene, Rusakiewicz Sylvie, Gronnier Caroline, Goéré Diane, Mariette Christophe, Zitvogel Laurence, Kroemer Guido
Abstract excerpt
Ever accumulating evidence indicates that the long-term effects of radiotherapy and chemotherapy largely depend on the induction (or restoration) of an anticancer immune response. Here, we investigated this paradigm in the context of esophageal carcinomas treated by neo-adjuvant radiochemotherapy, in a cohort encompassing 196 patients. We found that the density of the FOXP3+ regulatory T cell (Treg) infiltrate...
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