Article
SMARCB1 Gene Mutation Predisposes to Earlier Development of Glioblastoma: A Case Report of Familial GBM.
Journal of neuropathology and experimental neurology - 1 May 2020
Mukherjee Sanjib, Stroberg Edana, Wang Fengfei, Morales Linden, Shan Yuan, Rao Arundhati, Huang Jason H, Wu Erxi, Fonkem Ekokobe
Abstract excerpt
Glioblastoma (GBM) is the most aggressive adult brain tumor. While GBM typically occurs sporadically, familial GBM can be associated with certain hereditary disorders and isolated familial GBMs in the absence of syndrome are rare. Relevant hereditary factors have remained elusive in these cases. Understanding specific genetic abnormality may potentially lead to better treatment strategies in these patients. Here,...
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