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Article

Two subphenotypes of septic acute kidney injury are associated with different 90-day mortality and renal recovery.

Critical care (London, England) - 15 Apr 2020

Wiersema Renske, Jukarainen Sakari, Vaara Suvi T, Poukkanen Meri, Lakkisto Päivi, Wong Hector, Linder Adam, van der Horst Iwan C C, Pettilä Ville

Abstract excerpt

BACKGROUND: The pathophysiology of septic acute kidney injury is inadequately understood. Recently, subphenotypes for sepsis and AKI have been derived. The objective of this study was to assess whether a combination of comorbidities, baseline clinical data, and biomarkers could classify meaningful subphenotypes in septic AKI with different outcomes. METHODS: We performed a post hoc analysis of the prospective...

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PMID: 32295614
DOI: 10.1186/s13054-020-02866-x
PMCID: PMC7161019

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