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Article

Extinction of all infectious HIV in cell culture by the CRISPR-Cas12a system with only a single crRNA.

Nucleic acids research - 4 Jun 2020

Gao Zongliang, Fan Minghui, Das Atze T, Herrera-Carrillo Elena, Berkhout Ben

Abstract excerpt

The CRISPR-Cas9 system has been used for genome editing of various organisms. We reported inhibition of the human immunodeficiency virus (HIV) in cell culture infections with a single guide RNA (gRNA) and subsequent viral escape, but complete inactivation of infectious HIV with certain combinations of two gRNAs. The new RNA-guided endonuclease system CRISPR-Cas12a (formerly Cpf1) may provide a more promising tool...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32282899
DOI: 10.1093/nar/gkaa226
PMCID: PMC7261156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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