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Inhibition of HIV-1 replication using the CRISPR/cas9-no NLS system as a prophylactic strategy

31 Aug 2022

Abstract excerpt

Globally, it is estimated that 43 million people are living with human immunodeficiency virus type 1 (HIV-1), and there are more than 600,000 acquired immunodeficiency syndrome (AIDS)-related deaths in 2020. The only way to increase the life expectancy of these patients right now is to use combination antiretroviral therapy (cART) for the lifetime. Due to the integration of the HIV-1 DNA in lymphocytes, the...

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PMID: 36158108
DOI: 10.1016/j.heliyon.2022.e10483

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