Analysis of CYP450 gene allelic variants can predict ifosfamide toxicity in Mexican paediatric patients.

doi:10.1080/1354750X.2020.1754913

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Analysis of CYP450 gene allelic variants can predict ifosfamide toxicity in Mexican paediatric patients.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Jun 2020

Torres Espíndola Luz María, Rojo-Serrato Daniela, Álvaro-Heredia Antonio, Castillejos López Manuel de Jesús, de Uña-Flores Armando, Pérez-García Martin, Zapata-Tarres Marta, Cárdenas-Cardos Rocio, Granados Julio, Chávez-Pacheco Juan Luis, Salinas-Lara Citlaltepetl, de Arellano Israel Torres-Ramirez, Aquino-Gálvez Arnoldo

Abstract excerpt

Context: Ifosfamide (IFA) is an effective antineoplastic for solid tumours in children, although it is associated with high levels of systemic toxicity and causes death in some cases. Objective: The aim of this study was to determine whether the presence of certain allelic variants of genes CYP2B6, CYP2C9, CYP3A4 and CYP3A5 increases the risk of toxicity in children with solid tumours treated with...

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PMID: 32279544
DOI: 10.1080/1354750X.2020.1754913

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