Evaluation of KRAS, NRAS and BRAF mutational status and microsatellite instability in early colorectal carcinomas invading the submucosa (pT1): towards an in-house molecular prognostication for pathologists?

doi:10.1136/jclinpath-2020-206496

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Article

Evaluation of KRAS, NRAS and BRAF mutational status and microsatellite instability in early colorectal carcinomas invading the submucosa (pT1): towards an in-house molecular prognostication for pathologists?

Journal of clinical pathology - 1 Nov 2020

Bourhis Amélie, De Luca Caterina, Cariou Mélanie, Vigliar Elena, Barel Fanny, Conticelli Floriana, Marcorelles Pascale, Nousbaum Jean-Baptiste, Robaszkiewicz Michel, Samaison Laura, Badic Bogdan, Doucet Laurent, Troncone Giancarlo, Uguen Arnaud

Abstract excerpt

AIM: We aimed to study the prognostic value of KRAS, NRAS, BRAF mutations and microsatellite stable (MSS)/instable (MSI) in the field of colorectal cancer invading the submucosa (ie, pT1 colorectal cancer (CRC)). METHODS: We led a case-control study in tumour samples from 60 patients with pT1 CRC with (20 cases) and without (40 cases) metastatic evolution (5 years of follow-up) which were analysed for KRAS, NRAS,...

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PMID: 32273401
DOI: 10.1136/jclinpath-2020-206496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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