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Article

Trehalose improves human fibroblast deficits in a new CHIP-mutation related ataxia.

PloS one - 1 Jan 2014

Casarejos Maria Jose, Perucho Juan, López-Sendón Jose Luis, García de Yébenes Justo, Bettencourt Conceição, Gómez Ana, Ruiz Carolina, Heutink Peter, Rizzu Patrizia, Mena Maria Angeles

Abstract excerpt

In this work we investigate the role of CHIP in a new CHIP-mutation related ataxia and the therapeutic potential of trehalose. The patient's fibroblasts with a new form of hereditary ataxia, related to STUB1 gene (CHIP) mutations, and three age and sex-matched controls were treated with epoxomici...

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Identifiers

PMID: 25259530
DOI: 10.1371/journal.pone.0106931
PMCID: PMC4178022

Genes

LAMP2
STUB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25259530-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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