Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility

10 Dec 2013

Abstract excerpt

Without baseline human immunity to the emergent avian influenza A(H7N9) virus, neuraminidase inhibitors are vital for controlling viral replication in severe infections. An amino acid change in the viral neuraminidase associated with drug resistance, NA-R292K (N2 numbering), has been found in some H7N9 clinical isolates. Here we assess the impact of the NA-R292K substitution on antiviral sensitivity and viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Disease Management and Epidemiology
Share to Influenza Virus Research Studies
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24326875
DOI: 10.1038/ncomms3854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibilityPMID 24326875Read ↗

Drug susceptibility profile and pathogenicity of H7N9 influenza virus (Anhui1 lineage) with R292K substitutionSemantic proximity Read ↗

Neuraminidase Mutations Conferring Resistance to Oseltamivir in Influenza A(H7N9) Viruses.Semantic proximity Read ↗

Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses.Semantic proximity Read ↗

The R292K Mutation That Confers Resistance to Neuraminidase Inhibitors Leads to Competitive Fitness Loss of A/Shanghai/1/2013 (H7N9) Influenza Virus in FerretsSemantic proximity Read ↗

Impact of neuraminidase mutations conferring influenza resistance to neuraminidase inhibitors in the N1 and N2 genetic backgrounds.Semantic proximity Read ↗

In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses.Semantic proximity Read ↗

Neuraminidase inhibitor resistance in influenza: a clinical perspectiveSemantic proximity Read ↗

A Novel Neuraminidase Deletion Mutation Conferring Resistance to Oseltamivir in Clinical Influenza A/H3N2 VirusSemantic proximity Read ↗

Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistanceSemantic proximity Read ↗

Genotypic and phenotypic susceptibility of emerging avian influenza A viruses to neuraminidase and cap-dependent endonuclease inhibitors.Semantic proximity Read ↗

Molecular mechanisms of influenza virus resistance to neuraminidase inhibitors.Semantic proximity Read ↗

Mutations of neuraminidase implicated in neuraminidase inhibitors resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.