Article
Complement C5a in the Sepsis Syndrome — Too Much of a Good Thing?
8 Jan 2003
Abstract excerpt
In sepsis, activation of the complement system introduces large amounts of C5a into the circulation. The excess of this peptide paralyzes neutrophils and increases susceptibility to infection. In tissues, by contrast, C5a has effects on neutrophils that protect against infection. Neutralization of circulating C5a by an antibody protects against the lethal effects of sepsis in an animal model.
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