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Recombinant Lactococcus Lactis Expressing M1-HA2 Fusion Protein Provides Protective Mucosal Immunity Against H9N2 Avian Influenza Virus in Chickens

24 Mar 2020

Abstract excerpt

The H9N2 subtype of the low pathogenic avian influenza virus (LPAIV) is distributed worldwide and causes enormous economic losses to the poultry industry. In this study, Lactobacillus expressing the H9N2 virus M1-HA2 fusion protein was used to investigate the impact on the protection effectiveness and mucosal immunity in chickens. Chickens orally vaccinated with NZ9000/pNZ8148-M1-HA2 showed significant increase...

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PMID: 32266297
DOI: 10.3389/fvets.2020.00153

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