Article
Oral immunization with an attenuated Salmonella Gallinarum encoding the H9N2 haemagglutinin and M2 ectodomain induces protective immune responses against H9N2 infection in chickens.
Avian pathology : journal of the W.V.P.A - 1 Oct 2020
Hajam Irshad Ahmed, Kirthika Perumalraja, Hewawaduge Chamith, Jawalagatti Vijayakumar, Park SungWoo, Senevirathne Amal, Lee John Hwa
Abstract excerpt
H9N2, a low pathogenic avian influenza virus, causes significant economic losses in the poultry industry worldwide. Herein, we describe the construction of an attenuated Salmonella Gallinarum (SG) strain for expression and delivery of H9N2 haemagglutinin (HA) 1 (SG-HA1), HA2 (SG-HA2) and/or the conserved matrix protein 2 ectodomain (SG-M2e). We demonstrated that recombinant SG strains expressing HA1, HA2 and M2e...
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