Article
Phenotype and functionality of follicular helper T cells in patients with acute dengue infection.
Journal of biomedical science - 8 Apr 2020
Wijesinghe Ayesha, Gamage Jayani, Goonewardena Hemantha, Gomes Laksiri, Jayathilaka Deshni, Wijeratne Dulharie T, de Alwis Ruklanthi, Jeewandara Chandima, Wijewickrama Ananda, Ogg Graham S, Malavige Gathsaurie Neelika
Abstract excerpt
BACKGROUND: The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied. METHODS: We investigated the phenotype and functionality of Tfh cells and plasmablasts in adult patients (DF = 18, DHF = 22) with acute dengue (day 4 to 8 since onset of fever) of varying severity using...
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