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Article

Novel Toscana Virus Reverse Genetics System Establishes NSs as an Antagonist of Type I Interferon Responses.

Viruses - 4 Apr 2020

Woelfl Franziska, Léger Psylvia, Oreshkova Nadia, Pahmeier Felix, Windhaber Stefan, Koch Jana, Stanifer Megan, Roman Sosa Gleyder, Uckeley Zina M, Rey Felix A, Boulant Steeve, Kortekaas Jeroen, Wichgers Schreur Paul J, Lozach Pierre-Yves

Abstract excerpt

The sand fly-borne Toscana virus (TOSV) is the major cause of human meningoencephalitis in the Mediterranean basin during the summer season. In this work, we have developed a T7 RNA polymerase-driven reverse genetics system to recover infectious particles of a lineage B strain of TOSV. The viral protein pattern and growth properties of the rescued virus (rTOSV) were found to be similar to those of the...

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Identifiers

PMID: 32260371
DOI: 10.3390/v12040400
PMCID: PMC7232479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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