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Article

Toscana Virus NSs Protein Inhibits the Induction of Type I Interferon by Interacting with RIG-I

4 Apr 2013

Abstract excerpt

Toscana virus (TOSV) is a phlebovirus, of the Bunyaviridae family, that is responsible for central nervous system (CNS) injury in humans. Previous data have shown that the TOSV NSs protein is a gamma interferon (IFN-β) antagonist when transiently overexpressed in mammalian cells, inhibiting IRF-3 induction (G. Gori Savellini, F. Weber, C. Terrosi, M. Habjan, B. Martorelli, and M. G. Cusi, J. Gen. Virol. 92:71-79,...

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Identifiers

PMID: 23552410
DOI: 10.1128/jvi.03129-12

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