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Article

Organoids as Models for Neoplastic Transformation

23 Feb 2016

Abstract excerpt

Cancer models strive to recapitulate the incredible diversity inherent in human tumors. A key challenge in accurate tumor modeling lies in capturing the panoply of homo- and heterotypic cellular interactions within the context of a three-dimensional tissue microenvironment. To address this challenge, researchers have developed organotypic cancer models (organoids) that combine the 3D architecture of in vivo...

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PMID: 26907527
DOI: 10.1146/annurev-pathol-012615-044249

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