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Article

RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers.

Molecular oncology - 1 Jun 2020

Biswas Kajal, Sharan Shyam K

Abstract excerpt

Adamson et al. report that BRCA2 mutation carriers inheriting RAD52 S346X variant have reduced breast cancer risk. The RAD52 S346X variant lacks the nuclear localization sequence, which mislocalizes the protein to the cytoplasm and renders it nonfunctional. Combined loss of BRCA2-mediated DNA repair by homologous recombination and RAD52-mediated single-strand annealing may result in cell death and reduce breast...

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Share to BRCA2 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32255263
DOI: 10.1002/1878-0261.12679
PMCID: PMC7266267

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