Article
Unveiling the Role of DJ-1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro-Tip Electrodes.
Angewandte Chemie (International ed. in English) - 26 Jun 2020
Yue Qingwei, Li Xianchan, Wu Fei, Ji Wenliang, Zhang Yue, Yu Ping, Zhang Meining, Ma Wenjie, Wang Ming, Mao Lanqun
Abstract excerpt
DJ-1 protein deficiency caused by PARK7 gene mutation has been suggested to closely relate to Parkinson's disease (PD), mainly through the attenuation D2 dopamine receptor activity in mice; however, whether or how it affects the vesicular storage and exocytosis of neurochemicals remains unclear. By using electrochemical methods at a single vesicle/cell level with nano/micro-tip electrodes, we for the first time...
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