Article
Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish.
Development (Cambridge, England) - 18 Jan 2021
Mukherjee Debanjan, Wagh Ganesh, Mokalled Mayssa H, Kontarakis Zacharias, Dickson Amy L, Rayrikar Amey, Günther Stefan, Poss Kenneth D, Stainier Didier Y R, Patra Chinmoy
Abstract excerpt
The ability of zebrafish to heal their heart after injury makes them an attractive model for investigating the mechanisms governing the regenerative process. In this study, we show that the gene cellular communication network factor 2a (ccn2a), previously known as ctgfa, is induced in endocardial cells in the injured tissue and regulates CM proliferation and repopulation of the damaged tissue. We find that,...
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