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Article

Paralog-aware assembly and filtering strategies reveal minimal nucleotide variation on the macro germline-restricted chromosome of the zebra finch.

Heredity - 1 Aug 2026

Chen Augustin, Ruiz-Ruano Francisco J, Contreras-López Orlando, Fouché Simone, Suh Alexander, Pei Yifan

Abstract excerpt

The germline-restricted chromosome (GRC) of passerines is a remarkable tissue-specific chromosome that accumulated paralogs of genes from the regular "A chromosomes" over millions of years, often amplified into dozens of gene copies. In addition to its repetitive content, typically uniparental inheritance, and lack of recombination, the GRC resembles non-recombining sex chromosomes and some B chromosomes, for all...

Read the complete abstract on PubMed

Topics

Animals
Finches
Polymorphism, Single Nucleotide
Chromosomes
Phylogeny
Haplotypes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Germ Cells

Sequence Analysis, DNA

Genetic Variation

Source

Open in PubMed Open full text

Identifiers

PMID: 41840191
DOI: 10.1038/s41437-026-00830-z
PMCID: PMC13545277

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