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Article

Identification of epigenetic factor KAT2B gene variants for possible roles in congenital heart diseases.

Bioscience reports - 30 Apr 2020

Hou Yong-Sheng, Wang Jing-Zhi, Shi Shuai, Han Ying, Zhang Yue, Zhi Ji-Xin, Xu Chao, Li Fei-Feng, Wang Gui-Yu, Liu Shu-Lin

Abstract excerpt

Congenital heart disease (CHD) is a group of anatomic malformations in the heart with high morbidity and mortality. The mammalian heart is a complex organ, the formation and development of which are strictly regulated and controlled by gene regulatory networks of many signaling pathways such as TGF-β. KAT2B is an important histone acetyltransferase epigenetic factor in the TGF-β signaling pathway, and alteration...

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Identifiers

PMID: 32239175
DOI: 10.1042/BSR20191779
PMCID: PMC7160239

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