Article
The diagnostic challenges and clinical course of a myeloid/lymphoid neoplasm with eosinophilia and ZBTB20-JAK2 gene fusion presenting as B-lymphoblastic leukemia.
Cold Spring Harbor molecular case studies - 1 Apr 2020
Lee Winston Y, Pfau Ruthann B, Choi Sarah M, Yang Jiong, Xiao Hong, Putnam Eileen M, Ryan Russell Jh, Bixby Dale L, Shao Lina
Abstract excerpt
We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer platform. This gene fusion from the same patient was recently identified by Peterson et al. (2019) at the genomic level using a different sequencing technology...
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