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Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6–LYN gene fusion

8 Apr 2016

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal haematopoietic stem cell disorders characterised by proliferation and maturation of different myeloid cell lineages. Classical MPNs are largely characterised by somatic mutation of JAK2, CALR or occasionally MPL genes. 1 , 2 MPNs can develop from chromosomal translocations forming gene fusions, involving constitutive activation and aberrant...

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PMID: 27058227
DOI: 10.1038/bcj.2016.11

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