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The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification

1 Apr 2020

Abstract excerpt

The precise control of eye size is essential for normal vision. TMEM98 is a highly conserved and widely expressed gene which appears to be involved in eye size regulation. Mutations in human TMEM98 are found in patients with nanophthalmos (very small eyes) and variants near the gene are associated in population studies with myopia and increased eye size. As complete loss of function mutations in mouse Tmem98...

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PMID: 32236127
DOI: 10.1371/journal.pgen.1008583

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