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Article

Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast.

Current genetics - 1 Aug 2020

Liu Ping, Sarnoski Ethan A, Olmez Tolga T, Young Thomas Z, Acar Murat

Abstract excerpt

Slowing down aging-associated accumulation of molecular damage or its prevention represents a promising therapeutic paradigm to combat aging-related disease and death. While several chemical compounds extend lifespan in model organisms, their mechanism of action is often unknown, reducing their therapeutic potential. Using a systematic approach, here we characterize the impact of the GMP pathway on yeast lifespan...

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Identifiers

PMID: 32232569
DOI: 10.1007/s00294-020-01068-w
PMCID: PMC7367712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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