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Polymorphism rs368234815 of interferon-λ4 gene and generation of antibodies to hepatitis B virus surface antigen in extracorporeal dialysis patients.

Expert review of vaccines - 1 Mar 2020

Grzegorzewska Alicja E, Świderska Monika K, Marcinkowski Wojciech, Mostowska Adrianna, Jagodziński Paweł P

Abstract excerpt

Background: The rs368234815 polymorphism of interferon-λ4 (IFN-λ4) gene (IFNL4) is involved in HBV surface antigen (HBsAg) clearance in non-uremic subjects. The rs368234815 ΔG/ΔG genotype can express IFN-λ4 while the TT/TT genotype cannot. We investigated whether rs368234815 is associated with the development of HBsAg antibodies (anti-HBs) in response to vaccination or infection, and HBsAg loss after infection in...

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Identifiers

PMID: 32228249
DOI: 10.1080/14760584.2020.1745637

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