Antibodies to hepatitis B virus surface antigen and interleukin 12 and interleukin 18 gene polymorphisms in hemodialysis patients.

doi:10.1186/1471-2369-13-75

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Article

Antibodies to hepatitis B virus surface antigen and interleukin 12 and interleukin 18 gene polymorphisms in hemodialysis patients.

BMC nephrology - 3 Aug 2012

Grzegorzewska Alicja E, Wobszal Piotr M, Mostowska Adrianna, Jagodziński Paweł P

Abstract excerpt

BACKGROUND: The interleukin (IL)18 rs360719 CC genotype is associated with the development of antibodies to hepatitis B virus surface antigen (anti-HBs) in hemodialysis (HD) patients. IL18 shares biological properties with IL12 in promoting the T-hepler 1 (Th1) system. We studied whether polymorphisms in the IL12A 3` untranslated region (UTR) and IL12B 3`UTR may contribute to anti-HBs development (titre ≥ 10...

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Identifiers

PMID: 22863216
DOI: 10.1186/1471-2369-13-75
PMCID: PMC3468411

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