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Article

Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD.

Respiratory research - 20 Apr 2021

Singh R, Belchamber K B R, Fenwick P S, Chana K, Donaldson G, Wedzicha J A, Barnes P J, Donnelly L E

Abstract excerpt

BACKGROUND: Lower airway bacterial colonisation (LABC) in COPD patients is associated with increased exacerbation frequency and faster lung function decline. Defective macrophage phagocytosis in COPD drives inflammation, but how defective macrophage function contributes to exacerbations is not clear. This study investigated the association between macrophage phagocytosis and exacerbation frequency, LABC and...

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Source

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Identifiers

PMID: 33879129
DOI: 10.1186/s12931-021-01718-8
PMCID: PMC8059282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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