Article
Association of the prophage BTP1 and the prophage-encoded gene, bstA, with antivirulence of Salmonella Typhimurium ST313.
Pathogens and disease - 1 Apr 2020
Spiegelhauer Malene R, García Vanesa, Guerra Priscila R, Olsen John E, Herrero-Fresno Ana
Abstract excerpt
The prophage BTP1 is highly conserved among strains of the pathogenic lineage Salmonella Typhimurium ST313. We aimed to analyze the role of BTP1 and the gene bstA(BTP1-encoded) in virulence of S. Typhimurium D23580, the ST313 lineage 2 reference strain. The deletion mutant D23580ΔbstA showed significantly higher replication and survival rates within human-derived THP-1 macrophages than the wild-type (WT) strain,...
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